USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: RACK1_HUMAN USC-OGP 2-DE database:  RACK1_HUMAN RACK1_HUMAN General information about the entry View entry in simple text format Entry name RACK1_HUMAN Primary accession number P63244 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Receptor of activated protein C kinase 1; AltName: Full=Cell proliferation-inducing gene 21 protein; AltName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1; AltName: Full=Guanine nucleotide-binding protein subunit beta-like protein 12.3; AltName: Full=Human lung cancer oncogene 7 protein; Short=HLC-7; AltName: Full=Receptor for activated C kinase; AltName: Full=Small ribosomal subunit protein RACK1 {ECO:0000303|PubMed:24524803}; Contains: RecName: Full=Receptor of activated protein C kinase 1, N-terminally processed; AltName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed;. Gene name Name=RACK1 {ECO:0000312|HGNC:HGNC:4399} Synonyms=GNB2L1 ORFNames=HLC7, PIG21 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1252: pI=7.02; Mw=30801 SPOT OGP-1254: pI=7.14; Mw=30714 Cross-references UniProtKB/Swiss-Prot P63244; RACK1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name RACK1_HUMAN Primary accession number P63244 Secondary accession number(s) B3KTJ0 D3DWS0 P25388 P99049 Q53HU2 Q5J8M6 Q5VLR4 Q6FH47 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 138) Name and origin of the protein Description RecName: Full=Receptor of activated protein C kinase 1; AltName: Full=Cell proliferation-inducing gene 21 protein; AltName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1; AltName: Full=Guanine nucleotide-binding protein subunit beta-like protein 12.3; AltName: Full=Human lung cancer oncogene 7 protein; Short=HLC-7; AltName: Full=Receptor for activated C kinase; AltName: Full=Small ribosomal subunit protein RACK1 {ECO:0000303|PubMed:24524803}; Contains: RecName: Full=Receptor of activated protein C kinase 1, N-terminally processed; AltName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed; Gene name Name=RACK1 {ECO:0000312|HGNC:HGNC:4399} Synonyms=GNB2L1 ORFNames=HLC7, PIG21 Encoded on Name=RACK1 {ECO:0000312|HGNC:HGNC:4399}; Synonyms=GNB2L1; ORFNames=HLC7, PIG21 Keywords 3D-structure; Acetylation; Apoptosis; Biological rhythms; Cell cycle; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Developmental protein; Direct protein sequencing; Gastrulation; Growth regulation; Host-virus interaction; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat; Translation regulation; WD repeat. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M24194; AAA59626.1; -; mRNA EMBL AY159316; AAO21313.1; ALT_INIT; mRNA EMBL AY336089; AAR24619.1; ALT_FRAME; mRNA EMBL AK095666; BAG53102.1; -; mRNA EMBL CR456978; CAG33259.1; -; mRNA EMBL CR541909; CAG46707.1; -; mRNA EMBL AK222488; BAD96208.1; -; mRNA EMBL CH471165; EAW53692.1; -; Genomic_DNA EMBL CH471165; EAW53702.1; -; Genomic_DNA EMBL BC000214; AAH00214.1; -; mRNA EMBL BC000366; AAH00366.1; -; mRNA EMBL BC010119; AAH10119.1; -; mRNA EMBL BC014256; AAH14256.1; -; mRNA EMBL BC014788; AAH14788.1; -; mRNA EMBL BC017287; AAH17287.1; -; mRNA EMBL BC019093; AAH19093.1; -; mRNA EMBL BC019362; AAH19362.1; -; mRNA EMBL BC021993; AAH21993.1; -; mRNA EMBL BC032006; AAH32006.1; -; mRNA CCDS CCDS34324.1; -; . PIR B33928; B33928; . RefSeq NP_006089.1; NM_006098.4; . UniGene Hs.5662; -; . PDB 4AOW; X-ray; 2.45 A; A/B/C=1-317 PDB 4UG0; EM; -; Sg=1-317 PDB 4V6X; EM; 5.00 A; Ag=1-317 PDB 5A2Q; EM; 3.90 A; g=1-315 PDB 5AJ0; EM; 3.50 A; Bg=1-317 PDB 5FLX; EM; 3.90 A; g=1-317 PDB 5T2C; EM; 3.60 A; AI=1-317 PDBsum 4AOW; -; . PDBsum 4UG0; -; . PDBsum 4V6X; -; . PDBsum 5A2Q; -; . PDBsum 5AJ0; -; . PDBsum 5FLX; -; . PDBsum 5T2C; -; . ProteinModelPortal P63244; -; . SMR P63244; -; . BioGrid 115671; 205; . DIP DIP-46736N; -; . IntAct P63244; 94; . MINT MINT-105673; -; . STRING 9606.ENSP00000426909; -; . iPTMnet P63244; -; . PhosphoSitePlus P63244; -; . SwissPalm P63244; -; . BioMuta GNB2L1; -; . DMDM 54037168; -; . REPRODUCTION-2DPAGE IPI00848226; -; . REPRODUCTION-2DPAGE P63244; -; . EPD P63244; -; . MaxQB P63244; -; . PaxDb P63244; -; . PeptideAtlas P63244; -; . PRIDE P63244; -; . TopDownProteomics P63244; -; . DNASU 10399; -; . Ensembl ENST00000512805; ENSP00000426909; ENSG00000204628; . GeneID 10399; -; . KEGG hsa:10399; -; . UCSC uc003mni.2; human; . CTD 10399; -; . DisGeNET 10399; -; . GeneCards RACK1; -; . HGNC HGNC:4399; RACK1; . HPA CAB004288; -; . HPA HPA021676; -; . MIM 176981; gene; . neXtProt NX_P63244; -; . OpenTargets ENSG00000204628; -; . PharmGKB PA28779; -; . eggNOG KOG0279; Eukaryota; . eggNOG ENOG410XQGZ; LUCA; . GeneTree ENSGT00840000129847; -; . HOVERGEN HBG000277; -; . InParanoid P63244; -; . KO K14753; -; . OMA ATSMENP; -; . PhylomeDB P63244; -; . TreeFam TF300600; -; . Reactome R-HSA-5357905; Regulation of TNFR1 signaling; . Reactome R-HSA-5357956; TNFR1-induced NFkappaB signaling pathway; . Reactome R-HSA-5626978; TNFR1-mediated ceramide production; . SignaLink P63244; -; . SIGNOR P63244; -; . ChiTaRS GNB2L1; human; . GeneWiki GNB2L1; -; . GenomeRNAi 10399; -; . PRO PR:P63244; -; . Proteomes UP000005640; Chromosome 5; . Bgee ENSG00000204628; -; . CleanEx HS_GNB2L1; -; . ExpressionAtlas P63244; baseline and differential; . Genevisible P63244; HS; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IMP:UniProtKB; . GO GO:0030425; C:dendrite; ISS:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:1990630; C:IRE1-RACK1-PP2A complex; IDA:ParkinsonsUK-UCL; . GO GO:0030496; C:midbody; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IMP:UniProtKB; . GO GO:0043025; C:neuronal cell body; ISS:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell; . GO GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB; . GO GO:0001891; C:phagocytic cup; IDA:UniProtKB; . GO GO:0015935; C:small ribosomal subunit; ISS:UniProtKB; . GO GO:0045296; F:cadherin binding; IDA:BHF-UCL; . GO GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; IMP:UniProtKB; . GO GO:0019899; F:enzyme binding; IPI:BHF-UCL; . GO GO:0008200; F:ion channel inhibitor activity; ISS:UniProtKB; . GO GO:0032947; F:protein complex scaffold; TAS:BHF-UCL; . GO GO:0042803; F:protein homodimerization activity; IDA:ParkinsonsUK-UCL; . GO GO:0005080; F:protein kinase C binding; IDA:UniProtKB; . GO GO:0019903; F:protein phosphatase binding; IPI:UniProtKB; . GO GO:0030292; F:protein tyrosine kinase inhibitor activity; IDA:UniProtKB; . GO GO:0005102; F:receptor binding; NAS:UniProtKB; . GO GO:0030971; F:receptor tyrosine kinase binding; IDA:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0042169; F:SH2 domain binding; IDA:UniProtKB; . GO GO:0035591; F:signaling adaptor activity; IMP:ParkinsonsUK-UCL; . GO GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB; . GO GO:0007049; P:cell cycle; IEA:UniProtKB-KW; . GO GO:0071333; P:cellular response to glucose stimulus; IDA:ParkinsonsUK-UCL; . GO GO:0071363; P:cellular response to growth factor stimulus; IDA:UniProtKB; . GO GO:0007369; P:gastrulation; IEA:UniProtKB-KW; . GO GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB; . GO GO:1900102; P:negative regulation of endoplasmic reticulum unfolded protein response; TAS:ParkinsonsUK-UCL; . GO GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB; . GO GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IGI:ParkinsonsUK-UCL; . GO GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IMP:ParkinsonsUK-UCL; . GO GO:0050765; P:negative regulation of phagocytosis; IMP:UniProtKB; . GO GO:0051898; P:negative regulation of protein kinase B signaling; IMP:UniProtKB; . GO GO:0017148; P:negative regulation of translation; ISS:UniProtKB; . GO GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB; . GO GO:0001649; P:osteoblast differentiation; IEA:Ensembl; . GO GO:0043473; P:pigmentation; IEA:Ensembl; . GO GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB; . GO GO:0030822; P:positive regulation of cAMP catabolic process; IMP:BHF-UCL; . GO GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB; . GO GO:2000304; P:positive regulation of ceramide biosynthetic process; TAS:Reactome; . GO GO:0051343; P:positive regulation of cyclic-nucleotide phosphodiesterase activity; IMP:BHF-UCL; . GO GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB; . GO GO:0042998; P:positive regulation of Golgi to plasma membrane protein transport; IMP:UniProtKB; . GO GO:0043547; P:positive regulation of GTPase activity; IDA:UniProtKB; . GO GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB; . GO GO:0051901; P:positive regulation of mitochondrial depolarization; IMP:UniProtKB; . GO GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB; . GO GO:0032464; P:positive regulation of protein homooligomerization; IDA:UniProtKB; . GO GO:0001934; P:positive regulation of protein phosphorylation; IDA:UniProtKB; . GO GO:0051726; P:regulation of cell cycle; IDA:UniProtKB; . GO GO:0051302; P:regulation of cell division; ISS:UniProtKB; . GO GO:2000114; P:regulation of establishment of cell polarity; ISS:UniProtKB; . GO GO:0032880; P:regulation of protein localization; ISS:UniProtKB; . GO GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0048511; P:rhythmic process; IEA:UniProtKB-KW; . GO GO:0006412; P:translation; IEA:Ensembl; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 2.130.10.10; -; 2; . InterPro IPR020472; G-protein_beta_WD-40_rep; . InterPro IPR015943; WD40/YVTN_repeat-like_dom; . InterPro IPR001680; WD40_repeat; . InterPro IPR019775; WD40_repeat_CS; . InterPro IPR017986; WD40_repeat_dom; . Pfam PF00400; WD40; 7; . PRINTS PR00320; GPROTEINBRPT; . SMART SM00320; WD40; 7; . SUPFAM SSF50978; SSF50978; 1; . PROSITE PS00678; WD_REPEATS_1; 4; . PROSITE PS50082; WD_REPEATS_2; 6; . PROSITE PS50294; WD_REPEATS_REGION; 1; .

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